ADHD Studies and References:
Health Stats Australia
Association of the Cannabinoid Receptor Gene (CNR1) with ADHD and post-traumatic stress disorder PTSD, Lu et. al. (2008 Dec.)
Cannabis Improves Symptoms of ADHD, P. Strohbeck-Kuehner and al., Cannabinoids (2008 Mar.)
Subtypes of Attention Deficit — Hyperactivity Disorder (ADHD) and cannabis use (PubMed)
Searching for a Neurobiological Basis for Self-Medication Theory in ADHD Comorbid With Substance Use Disorders (Pub Med)
Cannabidiol and clozapine reverse MK-801-induced deficits in social interaction and hyperactivity in Sprague-Dawley rats (PubMed)
Childhood and current ADHD symptom dimensions are associated with more severe cannabis outcomes in college students (PubMed)
Oral delta 9-tetrahydrocannabinol improved refractory Gilles de la Tourette syndrome in an adolescent by increasing intracortical inhibition: A case report (PubMed)
AIDs / HIV Studies and References
Cannabis in painful HIV-associated sensory neuropathy
Cannabis Use in HIV for Pain and Other Medical Symptoms
Marijuana Use and Its Association With Adherence to Antiretroviral Therapy Among HIV-Infected Persons With Moderate to Severe Nausea
Pharmacological Treatment of Painful HIV-Associated Sensory Neuropathy: A Systematic Review and Meta-Analysis of Randomised Controlled TrialsALS / MND Studies and References
Changes in Endocannabinoid Receptors and Enzymes in the Spinal Cord of SOD1G93A Transgenic Mice and Evaluation of a Sativex®-like Combination of Phytocannabinoids: Interest for Future Therapies in Amyotrophic Lateral Sclerosis
Medical Marijuana Utilization and Perceived Therapeutic Value in Patients with ALS (P3.014)Alzheimer’s Disease Studies and References:
Prevention of Alzheimer’s Disease Pathology by Cannabinoids: Neuroprotection Mediated by Blockade of Microglial Activation (2005)
The therapeutic potential of the endocannabinoid system for Alzheimer’s disease.(2012)
Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer’s disease.
Activation of the CB2 receptor system reverses amyloid-induced memory deficiency
Marijuana’s Active Ingredient Shown to Inhibit Primary Marker of Alzheimer’s Disease
Cannabinoids for treatment of Alzheimer’s disease: moving toward the clinic
Nonpsychotropic Cannabinoid Receptors RegulateMicroglial Cell MigrationAnorexia Nervosa Studies and References:
Leptin, ghrelin, and endocannabinoids: Potential therapeutic targets in anorexia nervosa (PubMed)
The role of the endocannabinoid system in eating disorders: Neurochemical and behavioural preclinical evidence (PubMed)Anxiety and Depression Studies and References:
Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug (PubMed)
Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis Sativa (PubMed)
Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients (PubMed)
Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder (PubMed)
Plant-based medicines for anxiety disorders, part 2: A review of clinical studies with supporting preclinical evidence (PubMed)Arthritis Studies and References:
Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis (PubMed)
The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis (PubMed)
Involvement of the endocannabinoid system in osteoarthritis pain (PubMed)Asthma Studies and References:
Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: Role for the adenosine A2A receptor
The role of cannabinoids in inflammatory modulation of allergic respiratory disorders, inflammatory pain and ischemic stroke (PubMed)
Allergen challenge increases anandamide in bronchoalveolar fluid of patients with allergic asthma (PubMed)
Bronchodilator effect of delta1-tetrahydrocannabinol (PubMed)Autism Spectrum Disorder Studies and References:
Mutations found in individuals with autism interfere with endocannabinoid signaling in the brain (Science Daily)
Cannabinoid receptor type 2, but not type 1, is up-regulated in peripheral blood mononuclear cells of children affected by autistic disorders (PubMed)
A novel approach to the symptomatic treatment of autism (Lester Grinspoon M.D., O’Shaughnessy’s)
Consequences of cannabinoid and monoaminergic system disruption in a mouse model of autism spectrum disorders (PubMed)
Targeting the endocannabinoid system in the treatment of fragile X syndrome (PubMed)
Autism Spectrum DisordersCancer Studies and References:
Enhancing the activity of cannabidiol and other cannabinoids in vitro through modifications to drug combinations and treatment schedules.
Scott KA, Shah S, Dalgleish AG, Liu WM. Anticancer Res. 2013 Oct;33(10):4373-80.
Cannabidiol as potential anticancer drug.
Massi P, Solinas M, Cinquina V, Parolaro D. Br J Clin Pharmacol. 2013 Feb;75(2):303-12
Cannabidiol, a Non-Psychoactive Cannabinoid Compound, Inhibits Proliferation and Invasion in U87-MG and T98G Glioma Cells through a Multitarget Effect.
Solinas M, Massi P, Cinquina V, Valenti M, Bolognini D, Gariboldi M, Monti E, Rubino T, Parolaro D. PLoS One. 2013 Oct 21;8(10):e76918.
Cannabinoids: a new hope for breast cancer therapy?
Caffarel MM, Andradas C, Pérez-Gómez E, Guzmán M, Sánchez C. Cancer Treat Rev. 2012 Nov;38(7):911-8
Towards the use of cannabinoids as antitumour agents.
Velasco G, Sánchez C, Guzmán M. Nat Rev Cancer. 2012 May 4;12(6):436-44.
Cannabidiol inhibits angiogenesis by multiple mechanisms.
Solinas M, Massi P, Cantelmo AR, Cattaneo MG, Cammarota R, Bartolini D, Cinquina V, Valenti M, Vicentini LM, Noonan DM, Albini A, Parolaro D. Br J Pharmacol. 2012 Nov;167(6):1218-31.
Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer.
Aviello G, Romano B, Borrelli F, Capasso R, Gallo L, Piscitelli F, Di Marzo V, Izzo AA. J Mol Med (Berl). 2012 Aug;90(8):925-34.
A combined preclinical therapy of cannabinoids and temozolomide against glioma.
Torres S, Lorente M, Rodríguez-Fornés F, Hernández-Tiedra S, Salazar M, García-Taboada E, Barcia J, Guzmán M, Velasco G. Mol Cancer Ther. 2011 Jan;10(1):90-103.
Stimulation of the midkine/ALK axis renders glioma cells resistant to cannabinoid antitumoral action.
Lorente M, Torres S, Salazar M, Carracedo A, Hernández-Tiedra S, Rodríguez-Fornés F, García-Taboada E, Meléndez B, Mollejo M, Campos-Martín Y, Lakatosh SA, Barcia J, Guzmán M, Velasco G. Cell Death Differ. 2011 Jun;18(6):959-73.
Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis.
McAllister SD, Murase R, Christian RT, Lau D, Zielinski AJ, Allison J, Almanza C, Pakdel A, Lee J, Limbad C, Liu Y, Debs RJ, Moore DH, Desprez PY. Breast Cancer Res Treat. 2011 Aug;129(1):37-47.
The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK.
Andradas C, Caffarel MM, Pérez-Gómez E, Salazar M, Lorente M, Velasco G, Guzmán M, Sánchez C. Oncogene. 2011 Jan 13;30(2):245-52
Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition.
Caffarel MM, Andradas C, Mira E, Pérez-Gómez E, Cerutti C, Moreno-Bueno G, Flores JM, García-Real I, Palacios J, Mañes S, Guzmán M, Sánchez C. Mol Cancer. 2010 Jul 22;9:196
Molecular mechanisms involved in the antitumor activity of cannabinoids on gliomas: role for oxidative stress.
Massi P, Valenti M, Solinas M, Parolaro D. Cancers (Basel). 2010 May 26;2(2):1013-26.
Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells.
Salazar M, Carracedo A, Salanueva IJ, Hernández-Tiedra S, Lorente M, Egia A, Vázquez P, Blázquez C, Torres S, García S, Nowak J, Fimia GM, Piacentini M, Cecconi F, Pandolfi PP, González-Feria L, Iovanna JL, Guzmán M, Boya P, Velasco G. J Clin Invest. 2009 May;119(5):1359-72.
Cannabinoids in intestinal inflammation and cancer.
Izzo AA, Camilleri M. Pharmacol Res. 2009 Aug;60(2):117-25.
Cannabinoids as potential new therapy for the treatment of gliomas.
Parolaro D, Massi P. Expert Rev Neurother. 2008 Jan;8(1):37-49.
Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression.
Blázquez C, Salazar M, Carracedo A, Lorente M, Egia A, González-Feria L, Haro A, Velasco G, Guzmán M. Cancer Res. 2008 Mar 15;68(6):1945-52.
Cannabinoids and gliomas.
Velasco G, Carracedo A, Blázquez C, Lorente M, Aguado T, Haro A, Sánchez C, Galve-Roperh I, Guzmán M. Mol Neurobiol. 2007 Aug;36(1):60-7.
Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells.
McAllister SD, Christian RT, Horowitz MP, Garcia A, Desprez PY. Mol Cancer Ther. 2007 Nov;6(11):2921-7.
Cannabinoids induce glioma stem-like cell differentiation and inhibit gliomagenesis.
Aguado T, Carracedo A, Julien B, Velasco G, Milman G, Mechoulam R, Alvarez L, Guzmán M, Galve-Roperh I. J Biol Chem. 2007 Mar 2;282(9):6854-62.
Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation.
Caffarel MM, Sarrió D, Palacios J, Guzmán M, Sánchez C. Cancer Res. 2006 Jul 1;66(13):6615-21.
A pilot clinical study of Delta9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme.
Guzmán M, Duarte MJ, Blázquez C, Ravina J, Rosa MC, Galve-Roperh I, Sánchez C, Velasco G, González-Feria L. Br J Cancer. 2006 Jul 17;95(2):197-203.COPD (Chronic Obstructive Pulmonary Disease) Studies and References:
Cannabinoid effects on ventilation and breathlessness: a pilot study of efficacy and safety.
Endocannabinoid anandamide mediates hypoxic pulmonary vasoconstrictionCrohn’s Disease Studies and References:
Cannabis induces a clinical response in patients with Crohn’s
High incidence of inflammatory bowel disease in Australia: a prospective population-based Australian incidence study.
Cannabis finds its way into treatment of Crohn’s disease (PubMed)
Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis (PubMed)Diabetes Studies and References:
The cannabinoid Δ(9)-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity.
The endocannabinoid system in energy homeostasis and the etiopathology of metabolic disorders.
Cannabinoids and Endocannabinoids in Metabolic Disorders with Focus on Diabetes
Peripheral effects of the endocannabinoid system in energy homeostasis: adipose tissue, liver and skeletal muscle.
Cannabidiol arrests onset of autoimmune diabetes in NOD mice.